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. 2015 Feb;4(1):27–35. doi: 10.3978/j.issn.2218-6751.2014.11.03

Figure 1.

Figure 1

CT images of MPEs in the three treatment groups (A-C). Three days after injection of LLC cells into the pleural cavity, mice were randomly divided into three groups and intrapleurally administered 50 μL H-β-C, 8 mg/kg of L-ITCZ or 25 mg/kg of H-ITCZ, three times with a 3-day interval. Fourteen days following the inoculation of LLC cells, transverse CT images of the three groups of mice showed large pleural effusion in the H-β-C group (A). Pleural effusion was also observed in the L-ITCZ group (B), while the H-ITCZ group had little effusion (C). The mean MPE volume was clearly reduced in the H-ITCZ group and was significantly reduced in the L-ITCZ group compared to the H-β-C group (D). Columns represent the mean value of each group, bars ± SD. ***P<0.001. MPE, malignant pleural effusion; LLC, Lewis lung carcinoma; H-β-C, hydroxypropyl-β-cyclodextrin; L-ITCZ, low itraconazole; H-ITCZ, high itraconazole.