Table 1. Tumor-normal cell ratio and the EGFR mutation diagnostics: technology is the issue?

Technology	Quiagen (%)	Cobas (%)	Sanger (%)
Sensitivity	1	5	20
T/N ratio
1:0 (rare)	1	5	20
1:1	2	10	40
1:5	5	25	100 (rare)
1:10	10	50	NA

Data represent the minimal % of mutant tumor cells detectable by the technology.