Table 1. Tumor-normal cell ratio and the EGFR mutation diagnostics: technology is the issue?
Technology | Quiagen (%) | Cobas (%) | Sanger (%) |
---|---|---|---|
Sensitivity | 1 | 5 | 20 |
T/N ratio | |||
1:0 (rare) | 1 | 5 | 20 |
1:1 | 2 | 10 | 40 |
1:5 | 5 | 25 | 100 (rare) |
1:10 | 10 | 50 | NA |
Data represent the minimal % of mutant tumor cells detectable by the technology.