Table 6.

Hydros-TA vs. Hydros: Observed mean reduction in WOMAC A (Pain) score*

Time point	Hydros n = 32	Hydros-TA n = 34	Difference	p -value
	Mean reduction (mm) from baseline [LSMeans(SE)]		Estimated between group difference [LSMeans(SE)]
Baseline	68.1	69.4	NA	NA
2 weeks	−23.3 (5.6)	−35.6 (5.2)	−12.4	0.04
6 weeks	−32.4 (5.6)	−33.4 (5.2)	−1.1	0.86
13 weeks	−33.9 (5.6)	−33.3 (5.2)	0.6	0.93
26 weeks	−32.4 (5.6)	−35.2 (5.3)	−2.8	0.65
Overall	−30.5 (5.1)	−34.4 (4.7)	−3.9	0.45

*For intent-to-treat population observed at landmark time points.