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. 2015 Feb 26;19(1):58. doi: 10.1186/s13054-015-0774-3

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© Fink et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Selenium administration reduces monocyte adhesion to the endothelium under flow conditions. Addition of selenium on human umbilical vein endothelial cells (HUVECs) diminished microparticles-induced monocyte-endothelial interaction (crosshatched bars) after stimulation with microparticles from resuscitated patients under venous flow (left and middle), as well as firm adherence under arterial flow (right) conditions in dynamic adhesion assay, compared with unblocked stimulation with microparticles from resuscitated patients (black bars) and to microparticle-free supernatant from resuscitated patients (dark gray bars). (**P <0.001; *P <0.01).