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. 2015 Feb 26;19(1):58. doi: 10.1186/s13054-015-0774-3

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© Fink et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Selenium administration reduces expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) after stimulation with microparticles. (A, B) Addition of selenium on human umbilical vein endothelial cells (HUVECs) diminished microparticle-induced ICAM-1 (left panels) and VCAM-1 (right panels) protein expression (checkered bars in each panel), shown by western blot analysis, compared with unblocked stimulation with microparticles or supernatant (black bars) from resuscitated patients (on the right in each panel) healthy controls (on the left), respectively. (C) Addition of selenium on HUVECs diminished microparticle-induced ICAM-1 (left panels; green staining by Cy2) and VCAM-1 (right panels; red staining by Cy3) protein expression after HUVEC stimulation with microparticles from resuscitated patients (lower right panels in each illustration), shown by immunocytochemistry, compared with unblocked stimulation with microparticles from resuscitated patients (lower left panels): 4,6-Diamidino-2-phenylindole (DAPI) was used for staining of nuclei. (**P <0.001; *P <0.01).