Table 1.
Summary statistics of the different datasets used in our study
| High confidence | High coverage | ||||||
|---|---|---|---|---|---|---|---|
| Dataset | Type | miRNAs | mRNAs | Interactions | miRNAs | mRNAs | Interactions |
| TarBase [21] | Validated | 202 | 2,315 | 9,569 | 202 | 2,315 | 9,569 |
| miRanda [6] | Predicted | 409 | 567 | 1,000 | 856 | 2,633 | 5,000 |
| miRGen [68] | Predicted | 503 | 37 | 1,041 | 828 | 103 | 5,230 |
| PicTar [69] | Predicted | 91 | 438 | 1,000 | 164 | 1,541 | 5,000 |
| PITA [70] | Predicted | 290 | 760 | 1,000 | 582 | 2,708 | 5,000 |
| TargetScan [71] | Predicted | 29 | 214 | 1,000 | 40 | 948 | 5,000 |
| Union (without TarBase) | Integrated | 926 | 1,818 | 4,983 | 1,505 | 6,063 | 24,553 |
| Expressed union (without TarBase) | Integrated | 163 | 448 | 701 | 240 | 2,034 | 4,337 |
| Union (with TarBase) | Integrated | 1,063 | 3,711 | 14,548 | 1,631 | 7,208 | 34,111 |
| Expressed union (with TarBase) | Integrated | 181 | 605 | 1,020 | 256 | 2,188 | 4,653 |
The integrated datasets involve data from all the prediction sets with or without the experimentally validated miRNA-target pairs. Among them, the expressed union sets were formed by considering only the expressed miRNAs and mRNAs in the corresponding union sets. We used these four expressed union sets (with or without TarBase, high confidence or high coverage) in our analyses.