Table 2.

Illustrating examples of using MTBs to functionally annotate miRNAs

Enriched GO term
MTB ID	Total number of mRNAs	mRNAs annotated with the GO term	miRNAs
GO:0004674 Protein serine/threonine kinase activity
1	4	AAK1, MAPK1, PDK3	miR-17, miR-20b, miR-93, miR-320a
GO:0000792 Heterochromatin
2	4	CBX5, HMGA2, RNF20	let-7b, let-7c, let-7d, let-7e, let-7g, miR-185
GO:0007219 Notch signaling pathway
3	3	CDK6, TNRC6B	miR-15a, miR-34a, miR-449a, miR-497
GO:0043161 Proteasome-mediated ubiquitin-dependent
protein catabolic process
4	19	EDEM1, UBE2W, WWP2	miR-25, miR-32, miR-363

Each row corresponds to one example MTB.