Table 6.
Rank | Gene set |
---|---|
1 | G protein coupled receptor activity |
6 | Rhodopsin like receptor activity |
14 | Peptide receptor activity |
2 | Apical junction complex |
3 | Apicolateral plasma membrane |
4 | Neurotransmitter binding |
5 | Neuropeptide receptor activity |
7 | Neurotransmitter receptor activity |
10 | Neuropeptide binding |
9 | KEGG neuroactive ligand receptor interaction |
11 | Reactome amine ligand binding receptors |
24 | Amine receptor activity |
12 | Intercellular junction |
8 | Tight junction |
13 | Structural constituent of muscle |
15 | Calcium channel activity |
16 | Feeding behavior |
18 | Voltage gated channel activity |
17 | Voltage gated potassium channel activity |
20 | Voltage gated cation channel activity |
19 | KEGG basal cell carcinoma |
21 | Contractile fiber |
22 | Anion transmembrane transporter activity |
23 | Reactome tight junction interactions |
25 | Digestion |
Negative enrichment: Western diet group vs. chronic control group.
The top 25 Western diet gene sets whose member genes are predominantly downregulated with respect to the chronic control group. Column 1 indicates the rank of the gene set based on Normalized Enrichment Score (NES). Column 2 lists the gene set name (bold) as provided by MSigDB. Gene set names and ranks that are not in bold are gene sets that are redundant or partially redundant and included within larger bolded gene sets. The NES ranged from -3.43 (for G Protein Coupled Receptor Activity, the top ranked gene set) to -1.92 (Digestion, the 25th-ranked gene set). FDR q range: 0 – 0.015.