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. 2014 Dec 24;15(1):1176. doi: 10.1186/1471-2164-15-1176

Table 6.

Gene set enrichment analysis

Rank Gene set
1 G protein coupled receptor activity
6   Rhodopsin like receptor activity
14   Peptide receptor activity
2 Apical junction complex
3 Apicolateral plasma membrane
4 Neurotransmitter binding
5   Neuropeptide receptor activity
7   Neurotransmitter receptor activity
10   Neuropeptide binding
9 KEGG neuroactive ligand receptor interaction
11 Reactome amine ligand binding receptors
24   Amine receptor activity
12 Intercellular junction
8   Tight junction
13 Structural constituent of muscle
15 Calcium channel activity
16 Feeding behavior
18 Voltage gated channel activity
17   Voltage gated potassium channel activity
20   Voltage gated cation channel activity
19 KEGG basal cell carcinoma
21 Contractile fiber
22 Anion transmembrane transporter activity
23 Reactome tight junction interactions
25 Digestion

Negative enrichment: Western diet group vs. chronic control group.

The top 25 Western diet gene sets whose member genes are predominantly downregulated with respect to the chronic control group. Column 1 indicates the rank of the gene set based on Normalized Enrichment Score (NES). Column 2 lists the gene set name (bold) as provided by MSigDB. Gene set names and ranks that are not in bold are gene sets that are redundant or partially redundant and included within larger bolded gene sets. The NES ranged from -3.43 (for G Protein Coupled Receptor Activity, the top ranked gene set) to -1.92 (Digestion, the 25th-ranked gene set). FDR q range: 0 – 0.015.