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Proposed model of cell proliferation in the presence and absence of sex steroids. (A) AR/ER driven expression of co-factors (green square) may be required for the modulation of cell proliferation by TrkB-TK+ and BDNF. (B) In the absence of sex steroids, downstream co-factors are not expressed, leading to cell proliferation that is not modulated by TrkB-TK+/BDNF expression and instead by other factors (yellow square).
