Table 5.
Overrepresented Gene Ontology (GO) categories in the hypermethylated genes in PA64S (S)
| GO term | Ontology a | Element | Ontology description | Number in input list | Number in BG/Ref | p-value |
|---|---|---|---|---|---|---|
| GO:0005750 | C | Down2k_ Down | mitochondrial respiratory chain complex III | 4 | 14 | 2.74e-05 |
| GO:0005746 | C | Down2k_ Down | mitochondrial respiratory chain | 3 | 22 | 0.00104 |
| GO:0005743 | C | Down2k_ Down | mitochondrial inner membrane | 5 | 78 | 0.00223 |
| GO:0016742 | F | 3’-UTR_ Down | hydroxymethyl-, formyl- and related transferase activity | 4 | 4 | 1.61e-14 |
| GO:0016741 | F | 3’-UTR_ Down | transferase activity, transferring one-carbon groups | 4 | 84 | 3.12e-08 |
| GO:0030528 | F | Intron_ Down | transcription regulator activity | 4 | 178 | 1.09e-05 |
| GO:0045153 | F | Down2k_ Down | electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity | 4 | 13 | 4.58e-05 |
| GO:0009853 | P | 3’-UTR_ Down | photorespiration | 4 | 4 | 3.65e-13 |
| GO:0046653 | P | 3’-UTR_ Down | tetrahydrofolate metabolic process | 4 | 4 | 3.65e-13 |
| GO:0006760 | P | 3’-UTR_ Down | folic acid and derivative metabolic process | 4 | 8 | 2.56e-11 |
| GO:0042558 | P | 3’-UTR_ Down | pteridine and derivative metabolic process | 4 | 11 | 1.20e-10 |
| GO:0043094 | P | 3’-UTR_ Down | cellular metabolic compound salvage | 4 | 19 | 1.41e-09 |
| GO:0006732 | P | 3’-UTR_ Down | coenzyme metabolic process | 4 | 63 | 2.17e-07 |
| GO:0009259 | P | 3’-UTR_ Down | ribonucleotide metabolic process | 4 | 81 | 6.08e-07 |
| GO:0051186 | P | 3’-UTR_ Down | cofactor metabolic process | 4 | 102 | 1.55e-06 |
| GO:0009117 | P | 3’-UTR_ Down | nucleotide metabolic process | 4 | 111 | 2.19e-06 |
| GO:0006725 | P | 3’-UTR_ Down | cellular aromatic compound metabolic process | 4 | 129 | 4.02e-06 |
| GO:0032787 | P | 3’-UTR_ Down | monocarboxylic acid metabolic process | 4 | 142 | 5.94e-06 |
| GO:0046483 | P | 3’-UTR_ Down | heterocycle metabolic process | 4 | 189 | 1.88e-05 |
| GO:0006122 | P | Down2k_ Down | mitochondrial electron transport, ubiquinol to cytochrome c | 4 | 6 | 2.35e-06 |
| GO:0042775 | P | Down2k_ Down | mitochondrial ATP synthesis coupled electron transport | 4 | 18 | 0.00045 |
| GO:0006119 | P | Down2k_ Down | oxidative phosphorylation | 4 | 28 | 0.00289 |
| GO:0042773 | P | Down2k_ Down | ATP synthesis coupled electron transport | 4 | 28 | 0.00289 |
a, C: cellular component; F, molecular function; P, biological process.