Table 3.
Allele and genotype frequencies of BRINP3 markers in the discovery sample
| Healthy (n = 93) | Diseased (n = 52) | Chronic periodontitis only (n = 36) | Peri-implantitis only (n = 34) | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | Healthy | Healthy | Healthy | Diseased | Diseased | Chronic periodontitis only | |
| X | X | X | X | X | X | |||||
| Diseased | Chronic periodontitis only | Peri-implantitis only | Peri-implantitis only | Chronic periodontitis only | Peri-implantitis only | |||||
| rs1342913 | ||||||||||
| AA | 31 (33.7) | 11 (22) | 12 (34.3) | 7 (21.2) | 0.29 | 0.25 | 0.34 | 0.6 | 0.2 | 0.08 |
| AG | 39 (42.4) | 27 (54) | 19 (54.3) | 15 (45.4) | ||||||
| GG | 22 (23.9) | 12 (24) | 4 (11.4) | 11 (33.4) | ||||||
| AG + GG | 61 (66.3) | 39 (78) | 23 (65.7) | 26 (78.8) | 0.14 | 0.94 | 0.1 | 0.93 | 0.2 | 0.2 |
| A | 101 (54.9) | 49 (49) | 43 (61.4) | 29 (44) | 0.34 | 0.34 | 0.12 | 0.5 | 0.1 | 0.04 |
| G | 83 (45.1) | 51 (51) | 27 (38.6) | 37 (56) | ||||||
| rs1935881 | ||||||||||
| CC | 7 (7.6) | 6 (12) | 7 (20) | 0 | 0.65 | 0.1 | 0.12 | 0.05 | 0.4 | 0.03 |
| CT | 40 (43.5) | 22 (44) | 11 (31.4) | 10 (33.3) | ||||||
| TT | 45 (48.9) | 22 (44) | 17 (48.6) | 20 (66.7) | ||||||
| CT + TT | 85 (92.4) | 44 (88) | 28 (80) | 30 (100) | 0.38 | 0.04 | 0.1 | 0.04 | 0.3 | 0.009 |
| C | 54 (29.3) | 34 (34) | 25 (35.7) | 10 (16.6) | 0.41 | 0.32 | 0.05 | 0.01 | 0.8 | 0.01 |
| T | 130 (70.6) | 66 (66) | 45 (64.3) | 50 (83.4) | ||||||
Diseased = chronic periodontitis + peri-implantitis.