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. 2014 Dec 22;15(1):1157. doi: 10.1186/1471-2164-15-1157

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© Ni et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Loss of HRDE-1 increases the levels of pre-mRNA and mRNA transcribed from the GRTS regions. (A) Percentages of sequenced tags (pre-mRNA-seq or mRNA-seq) that match to sequences of exons or introns. Scatter plots of the pre-mRNA-seq (B) or mRNA-seq signals (C) for the wild type and hrde-1(tm1200) mutant animals. (D-F) Scatter plots of the mRNA-seq signals for the wild type, nrde-2(gg91), nrde-3(gg66) and nrde-4(gg129) mutant animals. The percentage of the exemplary HRDE-1 targets showed at least 3-fold increases in mRNA-seq signals in each mutant was indicated in each panel.