Table 3. ADME Values for Selected Compounds^a.

	microsomal stability	plasma stability	PAMPA
compd	% remaining (1 h)	% remaining (3 h)	log Papp
4hh	7.9 ± 6.3	≥100	–7.33
4t	0.1 ± 0.1	≥100	N/A
4y	1.8 ± 2.1	97.9 ± 5.7	–7.12
4ee	1.8 ± 0.4	98.8 ± 3.7	–7.54
4ff	4.7 ± 1.7	≥100	–7.46
4jj	12.9 ± 1.6	≥100	–10.20

^aCompounds with highest relative potency were analyzed for stability in mouse microsomes and plasma, as well as for BBB permeability.