Table 1.
Genes significantly associated with CRS in prior studies
| Study [Ref] | Gene | Chromosome Location | Variation Surveyed | CRS Phenotype | Relevant Results OR (P value) | Involved Function |
|---|---|---|---|---|---|---|
| Pinto et al. 2008 [19] | CFTR | 7q31 | Multiple SNPs | CRSsNP | NA (.0023) | Chloride ion transport |
| Raman et al. 2002 [20] | CFTR | 7q31 | Multiple SNPs | CRS | 3.5 (<.05) | Chloride ion transport |
| Keles et al. 2008 [21] | HLA-C | 6p21 | Multiple SNPs | CRSwNP | NA (<.05) | Encoding human leukocyte antigens |
| Takeuchi et al. 1999 [22] | HLA-B | 6p21 | Multiple SNPs (HLA-B54) | CRS | 3.23 (<.037) | Encoding human leukocyte antigens |
| Luxenberger et al. 2000 [23] | HLA-A | 6p21 | Multiple SNPs (HLA-A74) | CRSwNP | 71.3 (<0.03) | Encoding human leukocyte antigens |
| Zhai et al. 2007 [24] | HLA-DR | 6p21 | HLA-DR*16 | CRSwNP | 8.9 (.03) | Encoding human leukocyte antigens |
| Schubert et al. 2004 [25] | HLA-DQ | 6p21 | HLA-DQB1*03 | CRSwNP | 4.25 (.001) | Encoding human leukocyte antigens |
| Monar-Gabor et al. 2000 [26] | HLA-DR | 6p21 | HLA-DR*7 | CRSwNP | 2.55 (<.05) | Encoding human leukocyte antigens |
| Fajardo-Dolci et al. 2006 [27] | HLA-DQ | 6p21 | HLA-DQA1*0201 | CRSwNP | 6.79 (.0027) | Encoding human leukocyte antigens |
| Pascual et al. 2008 [28] | NOS2A | 17q11-q12 | Promoter VNTR | CRSwNP | 14.39 (.001) | Innate immunity |
| Yazdani et al. 2012 [29] | CD14 | 5q31 | rs2569190 | CRSwNP | 1.88 (.04) | Innate immunity |
| Erbek et al. 2007 [30] | IL1A | 2q14 | rs17561 | CRSwNP | 2.743 (<.001) | Inflammation |
| Batikhan et al. 2010 [31] | TNF | 6q21 | rs1800629 | CRSwNP | 3.68 (.016) | Inflammation |
| Zhang et al. 2011 [32] | NOS1 | 12q24 | Multiple SNPs | CRS | Varied (.0023-.0129) | Innate immunity |
| Zhang et al. 2011 [32] | NOS1AP | 1q23 | rs4657164 | CRS | 1.67(.0178) | Innate immunity |
| Zielinska-Blizniewska et al. 2012 [33] | POSTN | 13q13 | −33C>G | CRSwNP | 4.56 (<.001) | Tissue remodeling |
| Kim et al. 2007 [34] | TGFB1 | 19q13 | rs1800469 | CRSsNP | NA (.012) | Tissue remodeling |
| Benito et al. 2012 [35] | PTGDR | 14q22 | Diplotype | CRSwNP | 2.44 (.043) | Arachidonic acid metabolism |
| Zhang et al. 2012 [36] | AOAH | 7q14-p12 | rs4504543 | CRSsNP | 0.03 (<.0001) | Others |
| Ozcan et al. 2010 [37] | GSTT1 | 22q11 | Homozygous deletion | CRSwNP | 2.03 (.05) | Others |
| Bosse et al. 2009 [38] | PARS2 | 1p32 | Rs2873551 | CRS | 0.49(.000026) | Others |
CRS, chronic rhinosinusitis; OR, odds ratio; CRSsNP, chronic rhinosinusitis without nasal polyp; NA, not applicable; CRSwNP, chronic rhinosinusitis with nasal polyp