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. 2015 Jan 15;11(5):3423–3431. doi: 10.3892/mmr.2015.3205

Table I.

Clinicopathological factors and serum HGF.

Factor n Serum HGF (pg/ml) P-value
Gastric cancer 110 391.02±68.44 <0.0001
Control 200 193.30±52.00
Stagea
 IA 55 381.21±65.92 NS
 IB 18 414.41±82.48
 II 16 378.28±47.01
 IIIA 9 404.64±65.95
 IIIB 6 402.38±93.44
 IV 6 412.94±71.45
Depth
 m 28 378.89±58.81 NS
 sm 31 384.87±69.89
 mp 11 386.97±98.72
 ss 18 403.36±54.88
 s 22 407.04±71.75
INFa
 α 22 369.65±68.93 <0.001 (α.β vs. γ)
 β 37 367.34±59.68
 γ 44 418.42±67.72
Histological type
 well 25 387.23±54.56 NS
 mod 26 379.56±80.35
 poor 45 399.25±70.48
 sig 6 404.95±74.10
 muc 3 361.36±77.65
 pap 4 396.12±54.23
Macroscopic type
 0 59 382.03±64.39 NS
 0-advanced 9 364.13±68.61
 1 4 426.32±66.53
 2 16 404.70±87.33
 3 10 402.00±43.63
 4 11 423.53±72.43
 5 1 335.54±0.000
Lymphatic invasion
 ly0 48 384.71±63.69 NS
 ly1 37 391.22±70.67
 ly2 21 398.01±76.63
 ly3 4 428.13±68.74
Venous invasion
 v0 89 387.92±67.32 NS
 v1 20 404.99±75.03
 v2 1 387.52±0.000
Lymph node metastasis
 n0 78 391.17±70.37 NS
 n1 17 382.79±58.94
 n2 13 394.60±68.08
 n3 0
 n4 2 431.73±116.00 NS
Peritoneal dissemination
 p0 105 389.37±68.19 NS
 p1 5 425.58±71.99
Tumor size, mm
 ≤–70 97 384.64±66.22 NS
 >70 10 428.09±61.82
a

Classification of INF was performed according to the General Rules for the Gastric Cancer Society by the Japanese Research Society for Gastric Cancer. Values are expressed as the mean ± standard deviation.

HGF, hepatocyte growth factor; NS, not significant; m, mucosa; sm, submucosa; mp, muscularis propria; ss, subserosa; s, serosa; INF, infiltrative growth pattern; INFα, expansive type (tumor margin is clear); INFβ, intermediate type; INFγ, invasive type (tumor margin is unclear); well, well-differentiated tubular adenocarcinoma; mod, moderately differentiated tubular adenocarcinoma; poor, poorly differentiated adenocarcinoma; sig, signet-ring cell carcinoma; muc, mucinous adenocarcinoma; pap, papillary adenocarcinoma.