Table I.
Clinicopathological factors and serum HGF.
| Factor | n | Serum HGF (pg/ml) | P-value |
|---|---|---|---|
| Gastric cancer | 110 | 391.02±68.44 | <0.0001 |
| Control | 200 | 193.30±52.00 | |
| Stagea | |||
| IA | 55 | 381.21±65.92 | NS |
| IB | 18 | 414.41±82.48 | |
| II | 16 | 378.28±47.01 | |
| IIIA | 9 | 404.64±65.95 | |
| IIIB | 6 | 402.38±93.44 | |
| IV | 6 | 412.94±71.45 | |
| Depth | |||
| m | 28 | 378.89±58.81 | NS |
| sm | 31 | 384.87±69.89 | |
| mp | 11 | 386.97±98.72 | |
| ss | 18 | 403.36±54.88 | |
| s | 22 | 407.04±71.75 | |
| INFa | |||
| α | 22 | 369.65±68.93 | <0.001 (α.β vs. γ) |
| β | 37 | 367.34±59.68 | |
| γ | 44 | 418.42±67.72 | |
| Histological type | |||
| well | 25 | 387.23±54.56 | NS |
| mod | 26 | 379.56±80.35 | |
| poor | 45 | 399.25±70.48 | |
| sig | 6 | 404.95±74.10 | |
| muc | 3 | 361.36±77.65 | |
| pap | 4 | 396.12±54.23 | |
| Macroscopic type | |||
| 0 | 59 | 382.03±64.39 | NS |
| 0-advanced | 9 | 364.13±68.61 | |
| 1 | 4 | 426.32±66.53 | |
| 2 | 16 | 404.70±87.33 | |
| 3 | 10 | 402.00±43.63 | |
| 4 | 11 | 423.53±72.43 | |
| 5 | 1 | 335.54±0.000 | |
| Lymphatic invasion | |||
| ly0 | 48 | 384.71±63.69 | NS |
| ly1 | 37 | 391.22±70.67 | |
| ly2 | 21 | 398.01±76.63 | |
| ly3 | 4 | 428.13±68.74 | |
| Venous invasion | |||
| v0 | 89 | 387.92±67.32 | NS |
| v1 | 20 | 404.99±75.03 | |
| v2 | 1 | 387.52±0.000 | |
| Lymph node metastasis | |||
| n0 | 78 | 391.17±70.37 | NS |
| n1 | 17 | 382.79±58.94 | |
| n2 | 13 | 394.60±68.08 | |
| n3 | 0 | ||
| n4 | 2 | 431.73±116.00 | NS |
| Peritoneal dissemination | |||
| p0 | 105 | 389.37±68.19 | NS |
| p1 | 5 | 425.58±71.99 | |
| Tumor size, mm | |||
| ≤–70 | 97 | 384.64±66.22 | NS |
| >70 | 10 | 428.09±61.82 | |
Classification of INF was performed according to the General Rules for the Gastric Cancer Society by the Japanese Research Society for Gastric Cancer. Values are expressed as the mean ± standard deviation.
HGF, hepatocyte growth factor; NS, not significant; m, mucosa; sm, submucosa; mp, muscularis propria; ss, subserosa; s, serosa; INF, infiltrative growth pattern; INFα, expansive type (tumor margin is clear); INFβ, intermediate type; INFγ, invasive type (tumor margin is unclear); well, well-differentiated tubular adenocarcinoma; mod, moderately differentiated tubular adenocarcinoma; poor, poorly differentiated adenocarcinoma; sig, signet-ring cell carcinoma; muc, mucinous adenocarcinoma; pap, papillary adenocarcinoma.