Fig. 1.

NorUDCA ameliorates liver histology of chronically Schistosoma mansoni infected NMRI mice. (A) Representative liver histology images (HE; original magnification 100×), of female NMRI mice, 16 weeks after infection with 50 S. mansoni cercariae, receiving control diet and UDCA (0.5% wt/wt) or norUDCA (0.5% wt/wt) enriched diet for 4 weeks, are shown (original magnification 100×). In addition, a naive (uninfected) group was studied. (B) Infection with 50 S. mansoni cercariae resulted in uniformly infection levels in all infected groups, confirmed by antibody detection directed against parasite eggs. (C) Morphometric analysis of granuloma diameter revealed a significant reduction of granuloma size after norUDCA treatment compared to control and UDCA group. ^∗p <0.05 (vs. naive), ^#p <0.05 (vs. control), ^†p <0.05 (vs. UDCA).