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. 2015 Jan 12;11(5):3301–3307. doi: 10.3892/mmr.2015.3182

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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miR-34a inhibits the cycle phase transition from G0/G1 to S. (A–D) SW480 cells were treated with the negative control mimic (control), miR-34a mimic, 5-FU, or both, and were analyzed by flow cytometry to determine the percentage of cells in each of the different cell cycle phases, G1, S, and G2/M. (E) Bar diagram illutrating the distribution of cells from each group in the different cell cycle phases. (F) A model summarizing the findings from this study combined with previously published data, and describing the molecular interactions involved in cell cycle regulation. miR, microRNA; 5-FU, 5-fluorouracil; CDK, cyclin-dependent kinase; CCND1, cyclin D1.