Figure 8.

IL-18 and IL-15 regulate γδ T cell surveillance of mevalonate metabolism. IL-18 induces a pre-activated phenotype in γδ T cells, increases immunological responses to antigens as well as tolerance to oxidative stress, and enables proliferation under severe lymphopenic conditions; IL-15 converts central memory Vγ9Vδ2 T cells into effector cells, which produce with innate-like kinetics large amounts of interferon γ (IFNγ) upon antigen stimulation and display potent cytotoxicity against tumor cells.