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. 2014 Dec 17;3(11):e956012. doi: 10.4161/21624011.2014.956012

Figure 7.

Figure 7.

HER-3 peptide mimics delay tumor growth in 2 transplantable mouse models. SCID Mice (n = 5) at the age of 5–6 weeks old were challenged subcutaneously with either BXPC3 cells or JIMT-1 cancer cells and treated weekly with the indicated peptide mimics (200 μg) intravenously. Tumor growth was monitored over time. After euthanasia, tumors were extracted and weighed. Results displayed include average tumor volume over time (top panel) and % weight tumors when compared to total mouse weight (bottom panel). Error bars represent standard deviations from the mean. An irrelevant peptide (IRR) was used as a negative control. In BXPC3 mouse model, peptide treatment caused a significant delay in tumor growth with both peptide constructs HER-3 237–269 (p < 0.02) and HER-3 461–479 (p < 0.001), and the effects were also observed in percentage tumor weight per body mass; HER-3 237–269 (p < 0.05) and HER-3 461–479 (p < 0.04). Only the HER-3 461–479 construct was used in JIMT-1 mouse model, and it caused both a significant delay in tumor growth and % tumor weight (p = 0.02 and p < 0.05, respectively).