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. 2014 Dec 17;3(11):e956012. doi: 10.4161/21624011.2014.956012

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Figure 8. — HER-3 vaccine antibodies delay tumor growth in a transplantable mouse model. SCID Mice (n = 5) were challenged subcutaneously with either pancreatic (BXPC3) or breast (JIMT-1) cancer cells and treated weekly with the indicated peptide vaccine antibodies (500 μg) via IP injection. JIMT-1 cells and treated weekly with peptide vaccine antibodies. Tumor growth was monitored over time. After euthanasia, tumors were extracted and weighed. Results displayed include average tumor volume over time (top panel) and % weight tumors (bottom panel) when compared to total mouse weight (bottom panel). Error bars indicate standard deviation of the mean. Normal rabbit IgG (Pierce) was used as a negative control. In both mouse models, only treatment with the MVF-HER-3 461 vaccine antibodies caused a significant delay in tumor growth (p < 0.05 for both mouse models), and the effects were also observed in percentage tumor weight per body mass (p < 0.05).