Table 1.
The amino acid sequences of the synthetic peptide mimics and the chimeric peptides incorporating the MVF promiscuous T-cell epitopes with their molecular weights are depicted. Also shown are the amino acid sequences of the HER-1, HER-2 and IGF-1R peptides
| Peptides | Amino acid sequence of HER-3 peptides | Mol.wt (Da) |
|---|---|---|
| MVF-HER-3(237–269) | KLLSLIKGVIVHRLEGVE-GPSL-VPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVA-OH | 6099 |
| HER-3 (237–269) | Ac-VPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVA-OH | 3801 |
| MVF-HER-3 (461–479) | KLLSLIKGVIVHRLEGVE-GPSL-ERLDIKHNRPRRDCVAEGK-NH2 | 4672 |
| HER-3 (461–479) | Ac-ERLDIKHNRPRRDCVAEGK-NH2 | 2333 |
| HER-3 (99–122) | Ac-FVMLNYNTNSSHALRQLRLTQLTE-NH2 | 2891 |
| HER-3 (140–162) | Ac-DTIDWRDIVRDRDAEIVVKDNGR-NH2 | 2798 |
| Peptides | Amino acid sequence of EGFR (HER-1), HER-2 and IGF-1R peptides | Mol.wt(Da) |
| HER-1(418–435) | Ac-SLNITSLGLRSLKEISDG-NH2 | 1944 |
| MVF-HER-1(418–435) | KLLSLIKGVIVHRLEGVE-GPSL-SLNITSLGLRSLKEISDG-NH2 | 4242 |
| MVF-HER-2(597–626) | KLLSLIKGVIVHRLEGVE-GPSL-VARCPSGVKPDLSYMPIWKFPDEEGACQPL-NH2 | 5672 |
| MVF-HER-2(266–296) | KLLSLIKGVIVHRLEGVE-GPSL-LHCPALVTYNTDTFESMPNPEGRYTFGASCV-COOH | 5757 |
| IGF-1R 56–s81 | Ac-LLFRVAGLESLGDLFPNLTVIRGWKL-NH2 | 2969 |