Figure 1.

IGF-1R peptide mimics inhibit proliferation of pancreatic and breast cancer cells. The indicated cancer cells were incubated with insulin growth factor receptor 1(IGF-1R) peptide mimics and irrelevant peptide (IRR) at various concentrations (ranging from 25–150 μg/mL) and incubated for 3 d prior to the addition of the tetrazolium dye MTT. The proliferation inhibition rate was calculated using the formula (OD normal untreated- OD peptide treated / OD normal untreated) × 100. Results are an average of 2 different experiments with each treatment performed in triplicate;error bars represent the mean ± S.D.; irrelevant peptide was used as the negative control.