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. 2015 Mar 9;144(4):611–620. doi: 10.1111/imm.12412

Figure 6.

Figure 6

Protein kinase Cε (PKCε) regulates tumour necrosis factor-α (TNF-α) production in both monocyte subsets. (a) TNF-α production determined by ELISA in CD16− and CD16+ monocytes stimulated with 10 ng/ml LPS for 2, 4 and 8 hr. (b) Release of TNF-α in CD16− and CD16+ monocytes transfected with PKCε-small interfering RNA (siPKCε), PKCδ-siRNA (siPKCδ) or siRNA-Control (siCtrl) and subsequently stimulated with 10 ng/ml LPS for 8 hr. Data represent mean ± SEM (n = 3, *P < 0·05, **P < 0·01, ***P < 0·001).