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. 2015 Mar 9;144(4):677–686. doi: 10.1111/imm.12421

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Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

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Diminished frequencies of cytotoxic marker expressing natural killer (NK) cells in tuberculosis–diabetes mellitus (TB-DM). (a) A representative whole-blood intracellular cytotoxic marker flow data from a TB-DM individual showing NK cell expression of perforin, granzyme B and CD107a. (b) The baseline or antigen-stimulated net frequencies of NK cells expressing the cytotoxic markers perforin, granzyme B and CD107a are shown as scatter plots with the line representing the geometric mean of the frequency of NK cells expressing the respective marker in TB-DM (n = 22) and tuberculosis–no diabetes mellitus (TB-NDM) (n = 22) individuals. Net frequencies were calculated by subtracting baseline frequencies from antigen-stimulated frequencies. P-values were calculated using the Mann–Whitney test.