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. 2015 Mar 20;10(3):e0121416. doi: 10.1371/journal.pone.0121416

Table 5. Genes up-regulated by more than 15 folds in the adapted strain under the furfural and HMF stress.

Unigene number Gene Name Fold Change Pathway
13926 NADH dehydrogenase 17.5 Oxidative phosphorylation
17255 Ubiquinol-cytochrome c reductase cytochrome b/c1 subunit 17.1 Oxidative phosphorylation
22366 F-type H+-transporting ATPase subunit 17.1 Oxidative phosphorylation
14386 Cytochrome c oxidase cbb3-type subunit I 16.2 Oxidative phosphorylation
15065 NADH-ubiquinone oxidoreductase chain 4L 15.8 Oxidative phosphorylation
14058 Pyruvate dehydrogenase E2 component 17.6 TCA cycle
14702 Isocitrate dehydrogenase 16.6 TCA cycle
14018 2-oxoglutarate dehydrogenase E2 component 15.5 TCA cycle
21154 Fumarate hydratase 15.3 TCA cycle
22163 Methylsterol monooxygenase 18.6 Steroid biosynthesis
18887 Cytochrome P450, family 51 (sterol 14-demethylase) 17.1 Steroid biosynthesis
19394 Sterol 24-C-methyltransferase 15.7 Steroid biosynthesis
22559 3-oxoacyl-[acyl-carrier protein] reductase 15.7 Fatty acid biosynthesis
19017 Acetyl-CoA carboxylase 15.2 Fatty acid biosynthesis
12121 Calmodulin 18.5 Phosphatidylinositol signaling system
21176 Inositol-1,4,5-trisphosphate 5-phosphatase 15.0 Phosphatidylinositol signaling system
19354 Dihydroxyacetone kinase 16.3 Glycerolipid metabolism
10417 Triacylglycerol lipase 16.0 Glycerolipid metabolism
14508 1-acyl-sn-glycerol-3-phosphate acyltransferase 15.9 Glycerolipid metabolism
18484 Trehalose 6-phosphate synthase 15.9 Starch and sucrose metabolism
10819 Glycogen debranching enzyme 15.0 Starch and sucrose metabolism
22225 Phosphoglucomutase 16.8 Starch and sucrose metabolism
21978 P21-activated kinase 1 15.0 MAPK signaling pathway
10439 Osomolarity two-component system, response regulator SSK1 15.2 MAPK signaling pathway
21610 Zinc finger protein MSN2/4 15.1 MAPK signaling pathway
21803 ATP-binding cassette, subfamily G (WHITE), member 2, PDR 16.0 ABC transporters
10754 Transcription initiation factor TFIIE subunit beta 15.1 Basal transcription factors
22534 Small subunit ribosomal protein S20e 16.1 Ribosome
22171 Large subunit ribosomal protein L4e 16.1 Ribosome
22657 Small subunit ribosomal protein S3e 15.5 Ribosome
12327 Large subunit ribosomal protein L26e 15.9 Ribosome
12393 Large subunit ribosomal protein L11e 17.0 Ribosome
22501 Small subunit ribosomal protein S14e 16.4 Ribosome
22571 Large subunit ribosomal protein L30e 15.8 Ribosome
22393 Large subunit ribosomal protein L40e 16.3 Ribosome
22124 Small subunit ribosomal protein S27e 18.0 Ribosome
14476 Gamma-glutamyltranspeptidase 17.0 Glutathione metabolism
14702 Isocitrate dehydrogenase 16.6 Glutathione metabolism
19360 Glutathione reductase 15.9 Glutathione metabolism
22582 Spermidine synthase 15.7 Glutathione metabolism
10353 Cystathionine gamma-lyase 16.5 Cysteine and methionine metabolism
19280 Kynurenine-oxoglutarate transaminase 15.0 Tryptophan metabolism