Table 1.
Characteristics of patients with intrahepatic cholangiocarcinoma (ICC) at presentation (n = 82)
| Clinical, operative and pathological variables | At presentation | P-value | |
|---|---|---|---|
| Group 1 No recurrence n = 31 (38%) | Group 2 Recurrence n = 51 (62%) | ||
| Age, years, median (range) | 63 (44–77) | 60 (31–86) | 0.419 |
| Male gender, n (%) | 20 (64%) | 20 (39%) | 0.026 |
| Ethnicity, n (%) | |||
| White | 16 (52%) | 39 (77%) | 0.037 |
| Asian | 9 (31%) | 5 (10%) | |
| Other | 5 (17%) | 5 (10%) | |
| Symptoms at presentation, n (%) | 13 (42%) | 26 (51%) | 0.426 |
| Cirrhosis, n (%) | 4 (13%) | 3 (6%) | 0.261 |
| Extent of resection, n (%) | |||
| Right lobectomy | 12 (36%) | 13 (26%) | |
| Right trisectionectomy | 2 (6%) | 2 (6%) | |
| Left lobectomy | 7 (21%) | 16 (33%) | |
| Left trisectionectomy | 0 | 8 (16%) | |
| Segmentectomy | 8 (24%) | 6 (12%) | |
| Other | 4 (12%) | 5 (10%) | |
| Pringle manoeuvre, n (%) | 7 (87%) | 41 (80%) | 0.434 |
| Transfusion, n (%) | 10 (32%) | 15 (29%) | 0.786 |
| Solitary tumour nodule, n (%) | 29 (93%) | 44 (86%) | 0.307 |
| Tumour size, cm, median (range) | 7 (3–21) | 8 (3–17) | 0.405 |
| Histological differentiation, n (%) | 0.857 | ||
| Good | 1 (4%) | 2 (4%) | |
| Moderate | 12 (46%) | 25 (52%) | |
| Poor | 13 (50%) | 21 (44%) | |
| Vascular invasion, n (%) | 0.247 | ||
| None | 18 (58%) | 20 (39%) | |
| Microinvasion | 12 (39%) | 28 (55%) | |
| Macroinvasion | 1 (3%) | 3 (6%) | |
| Perineural invasion, n (%) | 7 (23%) | 15 (29%) | 0.498 |
| Lymph node involvement, n (%) | 6 (19%) | 15 (29%) | 0.312 |
| Satellite nodules, n (%) | 3 (10%) | 17 (33%) | 0.019 |
| Surgical margin, mm | |||
| Median (range) | 7 (0–35) | 6 (0–30) | 0.502 |
| Positive (R1), n (%) | 1 (3%) | 14 (28%) | 0.007 |
| Adjuvant chemotherapy ± radiotherapy | 1 (3%) | 22 (43%) | <0.001 |
| Follow-up, months, median (range) | 23 (1–116) | 29 (2–100) | 0.238 |