Table 3.

Predictors of survival after primary resection (n = 81) in univariate and multivariate analyses

Variable	n (number of events)	Survival, months, median (95% CI)	P-value
Age
≤60 years	33 (17)	52 (32–73)	0.330
>60 years	48 (31)	27 (5–50)
Gender			0.586
Male	39 (25)	27 (2–52)
Female	42 (23)	46 (23–70)
Underlying liver disease			0.131
None	56 (37)	31 (19–44)
Present	25 (11)	97 (26–168)
Number of tumours
Single	73 (42)	41 (15–67)	0.153
Multiple	9 (7)	27 (3–51)
Recurrence
Yes	51 (35)	38 (23–54)	0.193
No	30 (13)	>median
Positive margin
Yes	19 (11)	38 (6–70)	0.850
No	60 (35)	41 (14–68)
Adjuvant treatment
Yes	23 (15)	31 (16–36)	0.241
No	58 (33)	46 (15–78)
Vascular invasion
Yes	42 (26)	24 (17–30)	0.020
No	38 (22)	57 (19–96)
Satellites
Yes	20 (12)	24 (18–30)	0.028
No	60 (35)	52 (30–74)
Perineural invasion
Yes	21 (15)	20 (12–27)	0.001a
No	60 (33)	55 (35–76)
Lymph node involvement
Yes	21 (11)	26 (14–37)	0.250
No	60 (37)	46 (26–66)
Symptoms
Yes	39 (23)	38 (14–62)	0.769
No	42 (25)	41 (12–71)
Differentiation
Good	3 (1)	22 (–)	0.824
Moderate	37 (21)	41 (29–54)
Poor	33 (19)	55 (32–79)
Size
≤5 cm	24 (14)	57 (9–106)	0.869
>5 cm	56 (33)	39 (20–58)
Cirrhosis
Yes	7 (4)	52 (0–111)	0.851
No	72 (43)	39 (20–58)
Transfusion requirement
No	56 (29)	55 (33–78)	0.014a
Yes	25 (19)	23 (10–36)
Extent of vascular invasion
No	37 (21)	57 (20–95)	0.027
Microvascular	40 (23)	27 (8–46)
Macrovascular	4 (4)	7 (0–26)

^aSignificant on multivariate analysis.

Perineural invasion (P = 0.015, odds ratio 2.403, 95% CI 1−5).

Transfusion requirement (P = 0.021, odds ratio 2.134, 95% CI 1–4).

95% CI, 95% confidence interval.