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(A-D) dose dependence on cell cycle in colorectal cell line SW620 and (E), in A549 non-small cell lung carcinoma cells. In the SW620 cell line there is a clear switch from G1 to G2 arrest with increasing concentration, particularly for largazole and largazole isostere, this was not observed to occur in the A549 non-small cell lung carcinoma line and cells remained arrested in G1.
