Table 3.
Parameter | Units | Largazole | Larg. Pep. Iso. | % Difference |
---|---|---|---|---|
Cmax | μg/ml | 5.4 | 4.8 | 12.5% |
AUC | min*μg/mL | 31.34 | 44.69 | −29.9% |
Alpha | 1/min | 0.336 | 0.248 | 35.5% |
Beta | 1/min | 0.006 | 0.005 | 20.0% |
Alpha HL | min | 2.06 | 2.80 | −26.4% |
Beta HL | min | 116 | 139 | −16.5% |
CL | mL/min/kg | 160 | 111 | 44.1% |
MRT | min | 84 | 108 | −22.2% |
Vss | L/kg | 13.45 | 12.10 | 11.1% |