Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2015 Jan 24;75(4):671–682. doi: 10.1007/s00280-015-2675-1

Table 3.

Two compartmental Model Parameters (Largazole vs. Largazole Peptide Isostere)

Parameter Units Largazole Larg. Pep. Iso. % Difference
Cmax μg/ml 5.4 4.8 12.5%
AUC min*μg/mL 31.34 44.69 −29.9%
Alpha 1/min 0.336 0.248 35.5%
Beta 1/min 0.006 0.005 20.0%
Alpha HL min 2.06 2.80 −26.4%
Beta HL min 116 139 −16.5%
CL mL/min/kg 160 111 44.1%
MRT min 84 108 −22.2%
Vss L/kg 13.45 12.10 11.1%