Table 1.
Characteristics of Patients with Thyroid Cancer of Follicular Cell Origin as the First and Only Primary Tumors by Thyroid Cancer-Related Mortality, SEER, 1988–2007
| Patient Characteristics | Thyroid Cancer-Related Mortality
|
Total (%) | |
|---|---|---|---|
| Alive (%)1 | Dead (%) | ||
|
| |||
| No. of patients (%) | 59,770 (97.2) | 1,753 (2.8) | 61,523 |
|
| |||
| Sex | |||
| Male | 12,954 (21.7) | 688 (39.2) | 13,642 (22.2) |
| Female | 46,816 (78.3) | 1,065 (60.8) | 47,881 (77.8) |
|
| |||
| Age, years | |||
| < 45 | 29,262 (49) | 96 (5.5) | 29,358 (47.7) |
| ≥45 | 30,508 (51) | 1,657 (94.5) | 32,165 (52.3) |
|
| |||
| Race/ethnicity (16) | |||
| White | 49,212 (83) | 1,425 (81.3) | 50,637 (83) |
| Black | 3,340 (5.6) | 114 (6.5) | 3,454 (5.7) |
| Other | 6,782 (11.4) | 213 (12.2) | 6,995 (11.5) |
|
| |||
| Histopathology2 | |||
| PTC and FVPTC | 48,516 (83.6) | 669 (38.1) | 49,185 (82.3) |
| FTC | 3,981 (7) | 177 (10.1) | 4,158 (7) |
| HCC | 1,752 (3) | 66 (3.8) | 1,818 (3) |
| Other subtypes | 3,564 (6.1) | 292 (16.7) | 3,856 (6.5) |
| ATC | 191 (0.3) | 549 (31.3) | 740 (1.2) |
|
| |||
| Tumor size | |||
| ≤1 cm | 18,739 (34) | 95 (7.7) | 18,834 (33.4) |
| >1–2 cm | 16,001 (29) | 158 (12.8) | 16,159 (28.7) |
| >2–4 cm | 15,069 (27.3) | 371 (29.9) | 15,440 (27.4) |
| >4 cm | 5,345 (9.7) | 615 (49.6) | 5,960 (10.6) |
|
| |||
| Extrathyroidal extension | |||
| Yes | 8,989 (15.4) | 843 (67.7) | 9,832 (16.4) |
| No | 49,547 (84.6) | 402 (32.3) | 49,949 (83.6) |
|
| |||
| Stage T1 tumor | |||
| Yes | 30,686 (55.9) | 103 (9.4) | 30,789 (54.9) |
| No | 24,251 (44.1) | 1,092 (90.6) | 25,343 (45.1) |
|
| |||
| Lymph node metastasis | |||
| Yes | 12,015 (31.5) | 752 (77.1) | 12,767 (32.6) |
| No | 26,119 (68.5) | 223 (22.9) | 26,342 (67.4) |
|
| |||
| Distant metastasis | |||
| Yes | 996 (2.1) | 381 (47) | 1,377 (2.9) |
| No | 45,947 (97.9) | 430 (53) | 46,377 (97.1) |
|
| |||
| Surgery | |||
| Less than lobectomy | 421 (0.9) | 53 (6.5) | 474 (1) |
| Lobectomy | 7,206 (15.3) | 96 (11.7) | 7,302 (15.2) |
| Subtotal or total thyroidectomy | 39,531 (83.8) | 669 (81.8) | 40,200 (83.8) |
|
| |||
| Radiotherapy | |||
| None | 28,667 (48.8) | 515 (30.1) | 29,182 (48.2) |
| Radioisotopes | 27,932 (47.5) | 589 (34.4) | 28,521 (47.1) |
| XRT3 | 853 (1.5) | 478 (27.9) | 1,331 (2.2) |
| Combined XRT3 and radioisotopes | 327 (0.6) | 95 (5.5) | 422 (0.7) |
| Other | 1,024 (1.7) | 35 (2) | 1,059 (1.7) |
|
| |||
| Median follow-up (range) in months | 55 (1–239) | 19 (1–226) | 54 (1–239) |
1
Percentage of parameter by mortality status
2
PTC: papillary thyroid cancer; FVPTC: follicular variant of papillary thyroid cancer; FTC: follicular thyroid cancer; HCC: Hürthle cell cancer; Other subtypes include columnar, insular, tall cell, and poorly differentiated thyroid cancer; ATC: anaplastic or undifferentiated thyroid cancer
3
XRT: external radiotherapy.