Table 4.
Multivariate Cox Proportional Hazard Regression Analysis of Clinical Characteristics and TC mortality in Patients with Primary PTC ≤ 2 cm.
| Patient Characteristics | Hazard Ratio | 95.0% CI for Exp (B)
|
P | |
|---|---|---|---|---|
| Lower | Upper | |||
|
| ||||
| Age ≥45 years* | 12.2 | 4.3 | 34.8 | < 0.01 |
|
| ||||
| Male | 0.8 | 0.4 | 1.6 | 0.48 |
|
| ||||
| Race/ethnicity | ||||
| Black (reference) | 0.59 | |||
| White | 1.5 | 0.2 | 11.5 | 0.68 |
| Other | 2.2 | 0.3 | 18.3 | 0.46 |
|
| ||||
| Tumor size | ||||
| ≤1 cm (reference) | ||||
| >1–2 cm | 0.8 | 0.4 | 1.7 | 0.61 |
|
| ||||
| Regional lymph node metastasis* | 5.4 | 2.5 | 11.8 | <0.01 |
|
| ||||
| Distant metastasis* | 6.4 | 2.8 | 14.4 | <0.01 |
|
| ||||
| Extrathyroidal extension* | 2.8 | 1.3 | 5.9 | <0.01 |
|
| ||||
| Subtotal or total thyroidectomy (reference) | 0.21 | |||
| Lobectomy | 2.4 | 0.9 | 6.7 | 0.09 |
| Less than lobectomy* | 13.7 | 1.7 | 110.6 | 0.01 |
|
| ||||
| Radiotherapy | ||||
| None (reference) | < 0.01 | |||
| Radioisotopes | 1.1 | 0.5 | 2.4 | 0.88 |
| XRT* | 8.9 | 3.1 | 25.1 | < 0.01 |
| Combined XRT and radioisotopes* | 8.1 | 2.1 | 31.4 | < 0.01 |
| Other | 2.9 | 0.3 | 24.6 | 0.34 |
*
Significant independent prognostic indicators