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. Author manuscript; available in PMC: 2015 Sep 19.
Published in final edited form as: Nature. 2014 Dec 22;519(7543):370–373. doi: 10.1038/nature14028

Figure 1. Resveratrol binds at the active site of TyrRS.

Figure 1

a, Cartoon illustration of the domain organization of Hs TyrRS. Both domains are connected by a linker of ~20 amino acids. b, Left, Electron density of co-crystal x-ray structures (2.1 A°) of TyrRS bound to cis-resveratrol and to L-tyrosine. Right, Resveratrol induced a local conformational change relative to bound tyrosine at the active site. c, Both serum starvation and resveratrol treatment (5 μM) facilitated the nuclear translocation of TyrRS with a concomitant increase in the PARylation of PARP-1.