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. Author manuscript; available in PMC: 2015 Sep 19.
Published in final edited form as: Nature. 2014 Dec 22;519(7543):370–373. doi: 10.1038/nature14028

Figure 3. Resveratrol and serum starvation mimic similar downstream signaling events mediated by PARP-1 activation.

Figure 3

a, Cartoon illustrating the molecular basis and the integration of different signaling pathways to mediate a TyrRS/PARP-1 activated stress response evoked by either resveratrol or different stress conditions. b, PARP-1 activating conditions enhance Tip60-mediated activation of ATM. c, Time course of poly-ADP-ribosylation status and associated signaling events as depicted in figure 3a after serum starvation and (d) resveratrol (1 μM) treatment.