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. Author manuscript; available in PMC: 2015 Sep 19.
Published in final edited form as: Nature. 2014 Dec 22;519(7543):370–373. doi: 10.1038/nature14028

Extended Data Figure 1. Resveratrol inhibits TyrRS activation.

Extended Data Figure 1

a, The ATP-PPi exchange assay as described in methods demonstrated the inhibitory effect of resveratrol on TyrRS and (b), resveratrol shifts the Km for tyrosine. c, Resveratrol binds TyrRS better than tyrosine. The apparent Ki for resveratrol was deduced by varying the concentration of RSV and plotting the slope of (1/v vs 1/[Tyr]) versus [RSV] as indicated.