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. Author manuscript; available in PMC: 2015 Sep 19.
Published in final edited form as: Nature. 2015 Mar 9;519(7543):334–338. doi: 10.1038/nature14214

Figure 1. Design of a new approach for meta-C–H activation.

Figure 1

a, Previously reported remote meta-C–H activation directed by a U-shaped template. b, The norbornene-mediated Catellani reaction functionalizes ortho-positions of aryl iodides. c, The development of a tailor-made ligand that switches the ortho-selectivity to meta-selectivity using norbornene as a transient mediator (this work). ArF, 4-(CF3)C6F4. The activated C–H bonds (blue) and the newly formed bonds (red) are highlighted.