Table 2. Mean values of FA, RD and MD in the volumes of interest (VOIs), derived from Johns Hopkins University (JHU, Baltimore, Maryland) white matter tractography Atlas of FSL [41, 42], which showed significant differences comparing the three groups of patients to healthy controls (HCs).
| VOIs (MNI x, y, z) | FA mean values (T values) | RD mean values (T values) | MD mean values (T values) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2A | 2B* | 3 | HCs | 2A* | 2B* | 3 | HCs | 2A* | 2B* | 3 | HCs | |
| CC body 0; −9; 28 | 0.4889 (2.57951) | 0.5077 | 0.48882 (2.17637) | 0.51987 | 0.00074 | 0.00072 | 0.00105 (2.19738) | 0.00101 | 0.0011 | 0.001 | 0.00117 (2.03213) | 0.00114 |
| Left CST (inferior VOI)** −7; −23; −29 | 0.54567 | 0.54627 | 0.53821 (2.09896) | 0.56732 | 0.00054 (1.4373) | 0.00052 | 0.00055 (2.21023) | 0.00051 | 0.00081 (1.32477) | 0.00078 | 0.00082 | 0.00079 |
| Left CST (superior VOI) ** −22; −33; 35 | 0.44143 (2.32483) | 0.44909 | 0.43361 (2.15339) | 0.45385 | 0.00059 (2.7912) | 0.00056 | 0.00060 (2.44686) | 0.00056 | 0.00079 (3.73685) | 0.00077 | 0.00080 (2,31510) | 0.00077 |
| Ponto−mesenchephalic junction 2; −28; 36 | 0.51765 | 0.50049 | 0.53165 (1.70243) | 0.55187 | 0.00052 (1.8639) | 0.00054 | 0,00053 (1.789) | 0.00048 | 0.00075 (1.60280) | 0.00076 | 0.00078 | 0.00074 |
| Left thalamic radiations −8; −9; 3 | 0.44482 | 0.45072 | 0.43890 (1.76817) | 0.46144 | 0.00062 | 0.00062 | 0.00065 (1.80531) | 0.00061 | 0.00086 | 0.00085 | 0.00087 (1.82558) | 0.00084 |
| Right thalamic radiations 7; −9; 4 | 0.44887 | 0.46616 | 0.44470 (1.89831) | 0.46963 | 0.00062 | 0.00060 | 0.00065 (1.88179) | 0.00061 | 0.00085 | 0.00084 | 0.00088 (1.99424) | 0.00085 |
| Left SLF −39; −14; 30 | 0.37914 (2.48682) | 0.38617 (1.68064) | 0.37017 (2.04754) | 0.39655 | 0.00062 | 0.00061 | 0.00064 (2.1832) | 0.0006 | 0.00078 (3.19022) | 0.00077 | 0.00077 (2.06701) | 0.00077 |
| Right SLF 50; −5; 27 | 0.37978 | 0.38754 | 0.37158 (1.99208) | 0.39201 | 0.00061 | 0.00061 | 0.00064 (1.98237) | 0.00060 | 0.00078 | 0.00077 | 0.00080 (1.92972) | 0.00078 |
| Left ILF −30; −69; −3 | 0.44682 | 0.44341 | 0.43250 (1.91777) | 0.45772 | 0.00075 | 0.00073 | 0.00079 (1.81535) | 0.00074 | 0.00101 | 0.00098 | 0.00104 (1.94866) | 0.00100 |
| Right ILF 31; −69; −3 | 0.46276 | 0.46223 | 0.44887 (1.89097) | 0.47409 | 0.00068 | 0.00066 | 0.00071 (1.83310) | 0.00065 | 0.00094 | 0.00091 | 0.00096 (1.93383) | 0.00091 |
| Left IFOF −28; −72; −2 | 0.38364 | 0.38461 (1.92436) | 0.37350 (1.91386) | 0.39329 | 0.00071 | 0.00071 | 0.00074 (1.81398) | 0.00070 | 0.00091 | 00009 | 0.00094 (1.88059) | 0.00091 |
| Right IFOF 29; 38; 3 | 0.38069 | 0.38653 | 0.39339 (1.79248) | 0.39339 | 0.00070 | 0.00069 | 0.00073 (1.7927) | 0.00069 | 0.0009 | 0.00088 | 0.00092 (1.87716) | 0.00089 |
| Right uncinate fasciculus 27; 13; −7 | 0.31557 | 0.31871 | 0.32374 (1.67958) | 0.32374 | 0.00074 | 0.00072 | 0.00077 (1.63183) | 0.00074 | 0.00089 | 0.00088 | 0.00093 (1.74693) | 0.00090 |
| Amigdala (left) −23; −8; 10 | 0.17423 | 0.18179 (2.54173) | 0.17768 (1.80887) | 0.17582 | 0.00119 (2.817) | 0.00119 (2.8035) | 0.00123 (1.59172) | 0.00113 | 0.00130 (1.7234) | 0.00130 (2.8803) | 0.00135 | 0.00123 |
| Amigdala (right) 26; −7; −9 | 0.16707 | 0.17126 | 0.16806 (2.25370) | 0.17027 | 0.00133 (3.214) | 0.00128 (2.7882) | 0.00137 | 0.00129 | 0.00144 (2.0019) | 0.00139 (2.754) | 0.00148 | 0.00140 |
T values, when significant, are indicated in brackets.
CC = corpus callosum; CST = corticospinal tract; IFOF = inferior fronto-occipital fasciculus; ILF = inferior longitudinal fasciculus; SLF = superior longitudinal fasciculus; VOI = volume of interest
*T values which resulted significant at an uncorrected level (p<0.001);
**Inferior VOI of CST extend from the pre- and post- central gyri to the cerebral peduncles; superior VOI of CST extend from the cerebral peduncles to the caudal portion of the pons.