Table 2. Summary of the protective efficacies induced by rAdV-SjTPI.opt priming-rSjTPI s.c. boosting vaccination strategy at different challenge time points.
| Group | Challenge time | No. of mice | Adult worms | Female worms | Eggs in liver | |||
|---|---|---|---|---|---|---|---|---|
| No. of worms | Reduction (%) | No. of worms | Reduction (%) | No. of eggs | Reduction (%) | |||
| Control | 2w | 10 | 25±2 | — | 13±1 | — | 52557±16623 | — |
| 6w | 10 | 30±2 | — | 15±1 | — | 59997±10037 | — | |
| 10w | 9 | 28±3 | — | 14±2 | — | 59762±12904 | — | |
| rAdV-SjTPI.opt + rSjTPI | 2w | 10 | 9±2 # , * | 66.01 | 4±1 # , * | 69.52 | 17042±4240 # | 67.57 |
| 6w | 10 | 11±2 # , * | 63.48 | 5±1 # , * | 63.93 | 25786±3427 # , & | 57.02 | |
| 10w | 10 | 15±3 # | 48.83 | 7±1 # | 50.39 | 27950±4126 # , & | 53.23 | |
# Statistically significant (P<0.01), compared with the control group at different challenge time point.
*Statistically significant (P<0.05), compared with the rAdV-SjTPI.opt priming-rSjTPI boosting strategy at 10 weeks after the last immunization.
& Statistically significant (P<0.05), compared with the rAdV-SjTPI.opt priming-rSjTPI boosting strategy at 2 weeks after the last immunization.