Table 1. Single-marker analysis of OCD association with catechol-O-methyltransferase and monoamine oxidase A single-nucleotide polymorphisms.
Gene | SNP | OR | CHISQ | P | CHISQ_PAR | P_PAR | CHISQ_COM | P_COM |
---|---|---|---|---|---|---|---|---|
COMT | rs737866 | 0.756 | 6.127 | 0.013 | 2.286 | 0.131 | 7.86 | 0.005 |
rs933271 | 1.238 | 3.191 | 0.074 | 0.222 | 0.637 | 3.413 | 0.065 | |
rs5993883 | 1.164 | 2.042 | 0.153 | 1.882 | 0.17 | 3.133 | 0.077 | |
rs740603 | 0.97 | 0.091 | 0.762 | 2.574 | 0.109 | 0.057 | 0.812 | |
rs4680 | 1.034 | 0.099 | 0.752 | 1 | 0.317 | 0.002 | 0.96 | |
rs4646316 | 0.851 | 1.766 | 0.184 | 0.143 | 0.706 | 1.325 | 0.25 | |
rs165774 | 0.988 | 0.012 | 0.911 | 0.037 | 0.847 | 0.026 | 0.872 | |
rs9332377 | 0.88 | 0.832 | 0.362 | 0.6 | 0.439 | 1.174 | 0.278 | |
MAO-A | rs1465107 | 0.957 | 0.066 | 0.798 | 0.4 | 0.527 | 0.277 | 0.599 |
rs1465108 | 1.016 | 0.008 | 0.929 | 0.026 | 0.873 | 0 | 1 | |
rs6323 | 1.014 | 0.007 | 0.934 | 1.4 | 0.237 | 0.2 | 0.655 | |
rs979606 | 1.094 | 0.269 | 0.604 | 0.471 | 0.493 | 0.024 | 0.877 | |
rs979605 | 1.103 | 0.343 | 0.558 | 0.641 | 0.423 | 0.022 | 0.882 |
SNP: single-nucleotide polymorphism; TDT: transmission/disequilibrium test; OR: TDT odds ratio; CHISQ: TDT chi-square value; P: TDT p value; CHISQ_PAR: parental discordance test chi-square value; P_PAR: parental discordance test p value; CHISQ_COM: combined test chi-square value; P_COM: combined test p value; COMT: catechol-O-methyltransferase; MAO-A: monoamine oxidase-A