Fig 2. Effect of CO on NF-κB activation in ileum mucosa and in mesenteric lymph nodes of endotoxin-injected mice.

Mice received by gavage 6.5 mg/kg CO (endotoxin-COL), 13 mg/kg CO (endotoxin-COM), 26 mg/kg CO (endotoxin-COH), or the vehicle (endotoxin-V) every other day 8 times followed by injection with endotoxin from S. typhimurium (i.p., 10 mg/kg body weight). Control mice were pretreated with vehicle (control-V) followed by injection with saline. Samples were collected at 12 h after injection. Data are means ± SDs for six mice in each group. #Significantly different from the control (p < 0.05). a, b, and c the same tissue not sharing the same letter are significantly different (p < 0.05).