Table 2. Peripheral Concentration of Nitrate/nitrite and Proinflammatory Cytokines of Control Mice or Endotoxin-Injected Mice That Did or Did Not Receive COa.
control-V | endotoxin-V | endotoxin-COL | endotoxin-COM | endotoxin-COH | |
---|---|---|---|---|---|
nitrate/nitrite (nmol/mL) | 40.6 ±21.8 | 624.0 ± 96.9 # a | 406.3±137.5b | 375.4 ±148.4b | 315.6 ± 76.6b |
IL-1β (pg/mL) | 62.6 ± 29.2 | 215.3 ±44.4 # a | 181.3 ±42.8 a | 119.6 ± 35.3b | 110.0 37.2b |
TNF-α (pg/mL) | 37.9 ± 10.5 | 474.5 ± 22.4 # a | 421.4 ± 61.9 a | 278. 5 ± 45.4b | 228.6 40.6b |
IFN-γ (pg/mL) | 1.63 ± 0.51 | 106.34 ± 8.25 # a | 71.42 ± 6.19b | 70.37 ± 2.39b | 68.67 2.90b |
IL-18 (pg/mL) | 45.3 ± 11.7 | 283.0 ± 78.60 # a | 167.4 ± 65.3b | 136.4 ± 47.5bc | 91.5 22.7c |
aValues are the mean ± SD for six mice per group.
control-V, control mice treated with vehicle; endotoxin-V, endotoxin-injected mice treated with vehicle; endotoxin-COL, endotoxin-injected mice treated with 6.5 mg/(kg bw) of CO; endotoxin-COM, endotoxin-injected mice treated with 13 mg/(kg bw) of CO; endotoxin-COH, endotoxin-injected mice treated with 26 mg/(kg bw) of CO.
#Significantly different from the control group (p < 0.05).
a, b, and c indicate the means within a row not sharing the same superscript letter are significantly different (p < 0.05).