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. 2015 Mar 20;10(3):e0120700. doi: 10.1371/journal.pone.0120700

Table 2. Peripheral Concentration of Nitrate/nitrite and Proinflammatory Cytokines of Control Mice or Endotoxin-Injected Mice That Did or Did Not Receive COa.

control-V endotoxin-V endotoxin-COL endotoxin-COM endotoxin-COH
nitrate/nitrite (nmol/mL) 40.6 ±21.8 624.0 ± 96.9 # a 406.3±137.5b 375.4 ±148.4b 315.6 ± 76.6b
IL-1β (pg/mL) 62.6 ± 29.2 215.3 ±44.4 # a 181.3 ±42.8 a 119.6 ± 35.3b 110.0 37.2b
TNF-α (pg/mL) 37.9 ± 10.5 474.5 ± 22.4 # a 421.4 ± 61.9 a 278. 5 ± 45.4b 228.6 40.6b
IFN-γ (pg/mL) 1.63 ± 0.51 106.34 ± 8.25 # a 71.42 ± 6.19b 70.37 ± 2.39b 68.67 2.90b
IL-18 (pg/mL) 45.3 ± 11.7 283.0 ± 78.60 # a 167.4 ± 65.3b 136.4 ± 47.5bc 91.5 22.7c

aValues are the mean ± SD for six mice per group.

control-V, control mice treated with vehicle; endotoxin-V, endotoxin-injected mice treated with vehicle; endotoxin-COL, endotoxin-injected mice treated with 6.5 mg/(kg bw) of CO; endotoxin-COM, endotoxin-injected mice treated with 13 mg/(kg bw) of CO; endotoxin-COH, endotoxin-injected mice treated with 26 mg/(kg bw) of CO.

#Significantly different from the control group (p < 0.05).

a, b, and c indicate the means within a row not sharing the same superscript letter are significantly different (p < 0.05).