Table 3. Inflammatory markers and biochemical characteristics of type 2 diabetic elderly patients in dependence on elderly or middle age onset of the diagnosis of the diabetes.
| All subjects | All subjects | depressive syndrome | depressive syndrome | depressive syndrome and MCI | depressive syndrome and MCI | MCI | MCI | Controls | Controls | Difference (p<0.001) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Onset of the diagnosis of the diabetes | middle age | elderly age | middle age | elderly age | middle age | elderly age | middle age | elderly age | middle age | elderly age | |
| Nr of patients | 115 | 161 | 31 | 26 | 11 | 14 | 28 | 34 | 45 | 87 | |
| CRP (mg/L) | 5.4±2.6 | 4.9±2.9 | 5.9±2.3 | 4.9±2.6 | 9±3.1 | 10.3±3.4 | 6.7±1.7 | 6.7±1.8 | 3.4±1.3 | 3.2±1.3 | a, b, c, d, e, f |
| IL-6 (pg/ml) | 4.8±2.3 | 4.5±2.6 | 5.3±1.7 | 5.1±1.6 | 7.6±1.4 | 8.9±2.1 | 6.9±1.1 | 6.8±1.2 | 2.7±1.2 | 2.7±1.3 | a, b, c, e, f |
| TNF-α (pg/ml) | 5.6±2.5 | 5.1±2.6 | 5.8±2.1 | 5.1±2.0 | 8.7±2.1 | 9.2±2.6 | 7.3±1.7 | 7.2±1.8 | 3.6±1.5 | 3.6±1.6 | a, b, c, d, e, f |
| HbA1c (%) | 7.3±0.6 | 7.1±0.6 | 7.1±0.6 | 6.9±0.6 | 7.9±0.7 | 8.1±0.7 | 7.7±0.7 | 7.6±0.6 | 7.1±0.5 | 6.9±0.4 | a, b, e, f |
| CHOL (mmol/L) | 10.4±2.2 | 10.1±2.1 | 12.0±2.1 | 11.8±2.2 | 11.2±2.2 | 10.3±2.1 | 9.7±2 | 10.4±2.3 | 9.7±1.9 | 9.5±1.6 | b, c, e |
| LDL (mmol/L) | 6.2±1.6 | 5.8±1.6 | 7.2±1.7 | 6.9±1.8 | 7.1±2.1 | 6.1±1.7 | 5.5±1 | 6±1.7 | 5.9±1.5 | 5.4±1.4 | b, c, e |
| TG (mmol/L) | 9.5±2.5 | 9.7±1.9 | 9.1±2.3 | 9.2±1.6 | 11.4±2.8 | 11.2±2.5 | 9.4±3 | 10.9±2.1 | 9.3±2.1 | 9.2±1.5 | a, b, e, f |
| HDL (mmol/L) | 2.6±0.5 | 2.4±0.4 | 2.7±0.3 | 2.6±0.4 | 2.2±0.5 | 2.1±0.4 | 2.5±0.7 | 2.1±0.5 | 2.7±0.4 | 2.6±0.4 | a, b, e, f |
a- comparing: depressive syndrome—MCI and depressive syndrome
b- comparing: depressive syndrome—MCI
c- comparing: depressive syndrome—controls
d- comparing: MCI and depressive syndrome—MCI
e- comparing: MCI and depressive syndrome-controls
f- comparing: MCI—controls
DM2—diabetes type 2, OAD- oral anti-diabetic drug, CVD—cardiovascular disease, HA- hypertension, BMI—body mass index, MoCA—Montreal Cognitive Assessment, GDS—Geriatric Depression Scale the Student’s or the Mann Whitney-U tests were used to assess differences between elderly and middle age onset in each group; The ANOVA test followed by post-hoc test was used to test for significant differences between all four groups: first—in elderly onset of diagnosis of diabetes, second—in middle age onset of diagnosis of diabetes.