Table 2. In vitro activities of 10 antimicrobial agents against all carbapenem-nonsusceptible Enterobacteriaceae (all species combined), K. pneumoniae, E. coli, E. cloacae, E. aerogenes, and C. freundii.
| Antimicrobial agents | Susceptibilities | Detailed MIC | ||||
|---|---|---|---|---|---|---|
| %R | %I | %S | MIC50 | MIC90 | Range | |
| All isolates (n = 1135) a | ||||||
| Ertapenem | 70.2 | 28.3 | 1.5 | 2 | 16 | 0.5 - > 128 |
| Imipenem | 14.4 | 12.9 | 72.8 | 1 | 4 | 0.06–128 |
| Meropenem | 8.5 | 2.4 | 89.2 | 0.125 | 2 | ≤ 0.03 - > 128 |
| Cefotaxime | 97.2 | 1.5 | 1.3 | 128 | > 128 | ≤ 0.03 - > 128 |
| Flomoxef | 90.8 | 5.2 | 4.1 | > 128 | > 128 | 0.25 - > 128 |
| Cefepime | 43.7 | 5.7 | 50.7 | 8 | 128 | ≤ 0.03 - > 128 |
| Amikacin | 17.4 | 1.1 | 81.5 | 2 | > 128 | 0.5 - > 128 |
| Ciprofloxacin | 61.9 | 3.8 | 34.4 | 32 | > 128 | ≤ 0.03 - > 128 |
| Colistin b | 8.6 | - | 91.4 | 0.5 | 1 | 0.25 - > 128 |
| Tigecycline | 9.2 | - | 90.8 | 1 | 1 | 0.06–16 |
| K. pneumoniae (n = 577) | ||||||
| Ertapenem | 76.8 | 22.4 | 0.9 | 2 | 64 | 0.5 - > 128 |
| Imipenem | 14.9 | 11.4 | 73.7 | 1 | 8 | 0.125–128 |
| Meropenem | 10.6 | 1.9 | 87.5 | 0.125 | 4 | ≤ 0.03 - > 128 |
| Cefotaxime | 98.3 | 1.6 | 0.2 | > 128 | > 128 | 1 - > 128 |
| Flomoxef | 89.3 | 7.3 | 3.5 | 128 | > 128 | 0.25 - > 128 |
| Cefepime | 63.3 | 5.6 | 31.2 | 32 | > 128 | 0.06 - > 128 |
| Amikacin | 31.1 | 1.4 | 67.4 | 2 | > 128 | 0.5 - > 128 |
| Ciprofloxacin | 86.7 | 2.1 | 11.3 | 128 | > 128 | ≤ 0.03 - > 128 |
| Colistin | 4.0 | - | 96.0 | 0.5 | 1 | 0.25 - > 128 |
| Tigecycline | 6.8 | - | 93.2 | 1 | 1 | 0.125–16 |
| E. cloacae complex (n = 267) | ||||||
| Ertapenem | 59.6 | 38.2 | 2.3 | 2 | 8 | 0.5–64 |
| Imipenem | 7.5 | 13.9 | 78.7 | 0.5 | 2 | 0.25–64 |
| Meropenem | 3.0 | 1.9 | 95.1 | 0.125 | 0.5 | ≤ 0.03 - > 128 |
| Cefotaxime | 96.3 | 1.5 | 2.3 | 128 | > 128 | ≤ 0.03 - > 128 |
| Flomoxef | 95.9 | 2.6 | 1.5 | > 128 | > 128 | 2 - > 128 |
| Cefepime | 15.4 | 7.1 | 77.5 | 2 | 32 | ≤ 0.03 - > 128 |
| Amikacin | 1.5 | 0.8 | 97.8 | 1 | 4 | 0.5 - > 128 |
| Ciprofloxacin | 19.5 | 5.6 | 74.9 | 0.125 | 16 | ≤ 0.03 - > 128 |
| Colistin | 18.0 | - | 82.0 | 1 | 128 | 0.25 - > 128 |
| Tigecycline | 15.7 | - | 84.3 | 1 | 4 | 0.125–16 |
| E. coli (n = 145) | ||||||
| Ertapenem | 78.6 | 21.4 | 0 | 2 | 16 | 1 - > 128 |
| Imipenem | 13.1 | 8.3 | 78.6 | 0.5 | 4 | 0.06–64 |
| Meropenem | 6.9 | 2.1 | 91.0 | 0.125 | 1 | ≤ 0.03–32 |
| Cefotaxime | 100 | 0 | 0 | > 128 | > 128 | 4 - > 128 |
| Flomoxef | 86.9 | 2.1 | 11 | > 128 | > 128 | 1 - > 128 |
| Cefepime | 44.8 | 4.8 | 50.3 | 8 | > 128 | 0.06 - > 128 |
| Amikacin | 3.5 | 0 | 96.6 | 2 | 8 | 1 - > 128 |
| Ciprofloxacin | 75.9 | 2.8 | 21.4 | 64 | > 128 | ≤ 0.03 - > 128 |
| Colistin | 0.7 | - | 99.3 | 0.5 | 1 | 0.25–32 |
| Tigecycline | 0 | - | 100 | 0.5 | 1 | 0.06–1 |
| E. aerogenes (n = 88) | ||||||
| Ertapenem | 44.3 | 53.4 | 2.3 | 1 | 32 | 0.5–128 |
| Imipenem | 17.1 | 20.5 | 62.5 | 1 | 8 | 0.25–16 |
| Meropenem | 9.1 | 2.3 | 88.6 | 0.125 | 2 | 0.03–8 |
| Cefotaxime | 92.1 | 2.3 | 5.7 | 64 | > 128 | 0.125 - > 128 |
| Flomoxef | 97.7 | 1.1 | 1.1 | 128 | > 128 | 8 - > 128 |
| Cefepime | 10.2 | 1.1 | 88.6 | 1 | 32 | 0.06 - > 128 |
| Amikacin | 0 | 0 | 100 | 2 | 4 | 1–16 |
| Ciprofloxacin | 19.3 | 9.1 | 71.6 | 0.125 | 8 | 0.03 - > 128 |
| Colistin | 3.4 | - | 96.6 | 1 | 1 | 0.25–8 |
| Tigecycline | 18.2 | - | 81.8 | 1 | 4 | 0.25–16 |
| C. freundii (n = 20) | ||||||
| Ertapenem | 50 | 50 | 0 | 1 | 8 | 1–64 |
| Imipenem | 20 | 25 | 55 | 1 | 8 | 0.25–16 |
| Meropenem | 10 | 0 | 90 | 0.125 | 1 | 0.03–8 |
| Cefotaxime | 100 | 0 | 0 | 128 | > 128 | 16 - > 128 |
| Flomoxef | 90 | 10 | 0 | > 128 | > 128 | 16 - > 128 |
| Cefepime | 20 | 5 | 75 | 2 | 32 | 0.125–128 |
| Amikacin | 15 | 5 | 80 | 2 | 64 | 1 - > 128 |
| Ciprofloxacin | 25 | 5 | 70 | 0.5 | 8 | 0.03–64 |
| Colistin | 10 | - | 90 | 1 | 2 | 0.25 - > 128 |
| Tigecycline | 10 | - | 90 | 0.5 | 2 | 0.125–16 |
a Including all species listed in Table 1.
bIncluding Morganella and Providencia isolates, which are intrinsically resistant to colistin