. 2015 Mar 20;10(3):e0121668. doi: 10.1371/journal.pone.0121668

Table 5. In vitro activities of 10 antimicrobial agents against bla _KPC-2 and bla _IMP-8 positive Enterobacteriaceae. ^a .

Antimicrobial agent	bla _KPC-2 positive isolates (n = 17) ^b						bla _IMP-8 positive isolates (n = 37) ^c
Antimicrobial agent	%R	%I	%S	MIC₅₀	MIC₉₀	MIC Range	%R	%I	%S	MIC₅₀	MIC₉₀	MIC Range
Carbapenem:
Ertapenem	100	0	0	> 128	> 128	32 - > 128	81.1	13.5	5.4	4	8	0.5–64
Imipenem	100	0	0	64	64	16–64	37.8	24.3	37.8	2	16	0.5–64
Meropenem	100	0	0	128	> 128	16 - > 128	2.7	10.8	86.5	0.5	2	0.125–4
Cephalosporins:
Cefotaxime	100	0	0	> 128	> 128	128 - > 128	100	0	0	128	> 128	8 - > 128
Flomoxef	100	0	0	> 128	> 128	64 - > 128	81.1	13.5	5.4	> 128	> 128	8 - > 128
Cefepime	100	0	0	128	> 128	32 - > 128	48.6	18.9	32.4	16	128	0.25 - > 128
Non-β-lactams:
Amikacin	17.6	5.9	76.5	2	> 128	1 - > 128	8.1	0	91.9	2	8	1 - > 128
Ciprofloxacin	94.1	0	5.9	128	> 128	0.5 - > 128	67.6	10.8	21.6	8	128	≤ 0.03 - > 128
Colistin	5.9	0	94.1	0.5	1	0.5 - > 16	5.4	0	94.6	1	1	0.5 - > 128
Tigecycline	5.9	0	94.1	1	1	0.25–8	27.0	0	73.0	1	4	0.25–8

^a Interpretive breakpoints are based on the 2012 CLSI criteria except colistin and tigecycline breakpoints for which the EUCAST breakpoints are used, while flomoxef breakpoints are based on Liao et al (JMII, 2006).

b including 16 K. pneumoniae and 1 E. coli.

c including 1 K. pneumoniae, 26 E. cloacae, 1 E. coli, 1 K. oxytoca, 4 C. freundii and 4 R. planticola.

Table 5. In vitro activities of 10 antimicrobial agents against bla KPC-2 and bla IMP-8 positive Enterobacteriaceae. a .

Table 5. In vitro activities of 10 antimicrobial agents against bla _KPC-2 and bla _IMP-8 positive Enterobacteriaceae. ^a .