Table 6. Carbapenem MICs (μg/mL) of 1135 carbapenem-nonsusceptible Enterobacteriaceae isolates with different ESBL, AmpC, and carbapenemase combination profiles.

No. of isolates	β-lactamase profile			Ertapenem			Imipenem			Meropenem
	bla ESBL	bla AmpC	bla Carb a	MIC50	MIC90	MIC range	MIC50	MIC90	MIC range	MIC50	MIC90	MIC range
22	+ b	-	+	>128	>128	0.5 - >128	32	64	1–64	64	>128	0.125 - >128
6	-	+ c	+	4	8	1–8	1	8	0.5–8	0.5	1	0.5–1
9	+	+ d	+	4	>128	1–128	8	64	2–64	1	128	0.5–128
20	-	-	+	4	32	0.5 - >128	1	16	0.5–64	0.5	4	0.25–64
113	+	-	-	2	16	1–128	0.5	2	0.06–32	0.25	4	0.06 - >128
316	-	+	-	2	8	0.5 - > 128	1	4	0.125–128	0.125	1	≤0.03–64
373	+	+	-	2	16	0.5 - >128	1	4	0.125–64	0.125	1	<0.03–32
276	-	-	-	2	8	0.5–128	0.5	4	0.125–64	0.125	1	≤0.03–16

^a bla _Carb, carbapenemase. The distribution of the carbapenemases genes were: KPC-2 (13), IMP-8 (6), VIM-1 (2), and NDM-1 (1) among the 22 bla _ESBL+ bla _AmpC- bla _Carb+ isolates; IMP-8 (6) among all 6 bla _ESBL- bla _AmpC+ bla _Carb+ isolates; IMP-8 (7) and KPC-2 (2) among the 9 bla _ESBL+ bla _AmpC+ bla _Carb+ isolates; and IMP-8 (18) and KPC-2 (2) among the 20 bla _ESBL- bla _AmpC- bla _Carb+ isolates.

^b Co-carriage of bla _ESBL included CTX-M+SHV (12 isolates), SHV (8), CTX-M (1), SHV+OXY-5 (1).

^c Co-carriage of bla _AmpC included ACT (5), and CMY (1)

^d Co-carriage of bla _ESBL and bla _AmpC included SHV+ACT (4), CTX-M+CMY (3), SHV+CMY (1), CTX-M+DHA (1)