Fig 4. Meta-analysis comparison of the breast cancer SE score with MammaPrint.
A) Survival analysis statistics for the SE score and MammaPrint over ER positive samples and ER negative samples separately, c-index denotes concordance index and p denotes p-value. B) & C) The plots display the concordance index for the SE score and MammaPrint in each data set alongside 95% confidence intervals. The overall concordance indices were derived and compared via meta-analysis using a random effects model. The vertical line denotes concordance index = 0.5, data sets where the confidence interval for the concordance index crosses this line did not reach significance. Meta-analysis reveals that the SE score performs comparably to MammaPrint in ER positive samples (B) and outperforms MammaPrint across ER negative samples (C).