Table 4. Impact of HR-HPV on Estimated Absolute Risk of High-Grade Cervical Disease in Women With: NILM Cytology and ASCUS or worse Cytology.
| Age Group, years | |||||
|---|---|---|---|---|---|
| HPV Test Result | 25–29 | 30–39 | 40–49 | 50–55 | Overall |
| CIN2 or worse | |||||
| 14HR HPV(+) | 5.7 (2.3–12.4) | 6.7 (3.3–13.7) | 7.7 (2.9–17.8) | 0.0 (0.0–15.5) | 6.1 (3.8–9.5) |
| HPV16(+) | 13.8 (4.5–32.6) | 18.2 (6.0–41.0) | 12.5 (0.7–53.3) | 0.0 (0.0–94.5) | 15.0 (7.5–27.1) |
| HPV18(+) | 20.0 (3.5–55.8) | 6.25 (0.3–32.3) | 25.0 (1.32–78.1) | 0.0 (0.0–94.5) | 12.9 (4.2–30.8) |
| HPV16(+)/HPV18(+) | 13.5 (5.1–29.6) | 13.9 (5.2–30.1) | 16.7 (2.9–49.1) | 0.0 (0.0–80.2) | 13.8 (7.6–23.2) |
| 12HR HPV(+) | 1.45 (0.1–8.9) | 3.8 (1.0–11.5) | 5.7 (1.5–16.6) | 0.0 (0.0–16.6) | 3.1 (1.4–6.5) |
| 14HR HPV(−) | 0.0 (0.0–1.0) | 0.0 (0.0–0.5) | 0.0 (0.0–0.4) | 0.0 (0.0–0.7) | 0.0 (0.0–0.1) |
| CIN2 or worse | |||||
| 14HR HPV(+) | 22.5 (11.4–38.9) | 16.2 (6.8–32.7) | 35.3 (15.3–61.4) | 50.0 (2.7–97.3) | 22.9 (15.2–32.8) |
| HPV16(+) | 16.7 (2.9–49.1) | 37.5 (10.2–74.1) | 66.7 (12.5–98.2) | -* | 30.4 (14.0–53.0) |
| HPV18(+) | 66.7 (12.5–98.2) | 20.0 (1.0–70.1) | 66.7 (12.5–98.2) | -* | 45.4 (18.1–75.4) |
| HPV16(+)/HPV18(+) | 28.6 (9.6–58.0) | 33.3 (11.3–64.6) | 66.7 (24.1–94.0) | -* | 37.5 (21.7–56.2) |
| 12HR HPV(+) | 19.2 (7.3–40.0) | 8.0 (1.4–27.5) | 18.2 (3.2–52.2) | 50.0 (2.7–97.3) | 15.6 (8.1–27.3) |
| 14HR HPV(−) | 0.0 (0.0–16.6) | 0.0 (0.0–18.5) | 0.0 (0.0–10.9) | 0.0 (0.0–34.4) | 0.0 (0.0–4.7) |
HPV = human papilloma virus; HR-HPV = high-risk HPV types; ASCUS = atypical squamous cells of undetermined significance; 14HR HPV(−) = HPV DNA test negative for the pooled 14 high-risk types; 14HR HPV(+) = HPV DNA test positive for the pooled 14 high-risk types; 12HR HPV(−) = HPV DNA test negative for the pooled 12 high-risk types except 16 and 18; 12HR HPV(+) = HPV DNA test positive for the pooled 12 high-risk types except 16 and 18; HPV16(+) = HPV DNA test positive for HPV 16; HPV18(+) = HPV DNA test positive for HPV 18; HPV16(+)/HPV18(+) = HPV DNA test positive for HPV16 and HPV18; HRHPV(+)/HPV16(+) = HPV DNA test positive for the pooled 12 high-risk types except 16 and 18 and for HPV16; HRHPV(+)/HPV18(+) = HPV DNA test positive for the pooled 12 high-risk types except 16 and 18 and for HPV18
*No HPV positive cases with ASCUS+ cytology and CIN2+