Table 7. Performance of various tests combinations for triage to colposcopy of HPV positive women for the detection of CIN2+.
| Sensitivity | PPV | RR | PLR | |
|---|---|---|---|---|
| CIN2 or worse | % (95%CI) | % (95% CI) | (95%CI) | (95%CI) |
| None (all HPV+ to colposcopy) | 100.0 (91.4–100.0) | 10.0 (7.3–13.3) | - | - |
| ASCUS or worse | 53.7 (37.4–69.3) | 10.4 (6.3–14.6) | 20.8 (11.4–37.8) | 11.2 (8.2–15.4) |
| LSIL or worse | 41.5 (26.3–57.9) | 18.5 (10.5–26.4) | 30.1 (16.7–54.0) | 21.9 (14.3–33.5) |
| HSIL or worse | 17.1 (5.6–25.6) | 46.7 (21.4–71.9) | 54.6 (28.9–103.2) | 80.5 (30.6–211.68) |
| HPV16+ | 39.0 (24.2–55.4) | 14.8 (8.1–21.5) | 23.1 (12.7–42.0) | 16.8 (10.9–25.9) |
| HPV16+ or ASCUS or worse | 75.6 (65.4–88.8) | 10.8 (7.2–14.4) | 40.2 (19.9–81.1) | 11.7 (9.5–14.5) |
| HPV16+ and ASCUS or worse | 17.1 (5.6–28.6) | 25.0 (9.0–41.0) | 29.3 (14.2–60.3) | 32.3 (14.5–71.6) |
| HPV16+ or LSIL or worse | 65.9 (51.3–80.4) | 15.1 (9.9–20.4) | 41.5 (22.1–77.7) | 17.3 (13.2–22.7) |
| HPV16+ and LSIL or worse | 14.3 (3.8–25.5) | 31.6 (10.7–52.5) | 36.0 (17.2–75.4) | 44.7 (17.8–111.7) |
| HPV16+ or HSIL or worse | 53.7 (38.4–68.9) | 18.8 (11.7–25.9) | 38.5 (21.4–69.2) | 22.4 (15.8–31.7) |
| HPV16+ and HSIL or worse | - | - | - | - |
| HPV16+ or HPV18+ | 58.5 (42.1–73.7) | 15.4 (9.7–21.0) | 34.9 (19.1–63.5) | 17.6 (12.9–23.9) |
| (HPV16+ or HPV18+) or ASCUS or worse | 92.6 (91.8–93.5) | 10.4 (7.1–13.7) | 54.9 (24.5–122.8) | 11.3 (9.4–13.5) |
| (HPV16+ or HPV18+) and ASCUS or worse | 29.3 (15.3–43.2) | 32.4 (17.3–47.5) | 44.4 (24.6–80.1) | 46.4 (25.1–85.9) |
| (HPV16+ or HPV18+) or LSIL or worse | 78.0 (65.4–90.7) | 14.5 (9.8–19.1) | 60.9 (29.5–126.4) | 16.4 (13.2–20.3) |
| (HPV16+ or HPV18+) and LSIL or worse | 22.0 (9.3–34.6) | 39.1 (19.2–59.1) | 48.7 (26.3–90.2) | 62.3 (28.6–135.7) |
| (HPV16+ or HPV18+) or HSIL or worse | 68.3 (54.0–82.5) | 17.4 (11.5–23.2) | 51.5 (27.2–97.5) | 20.4 (15.6–26.6) |
| (HPV16+ or HPV18+) and HSIL or worse | 7.3 (0.0–15.3) | 50.0 (10.0–90.0) | 52.7 (22.3–124.5) | 96.8 (20.1–465.3) |
CIN2+ = cervical intraepithelial neoplasia grade 2 or worse histology; PPV = Positive Predictive Value; RR = Relative Risk; PLR = Positive Likelihood Ratio; HPV = human papilloma virus; ASCUS or worse = atypical squamous cells of undetermined significance or worse cytology; LSIL or worse = low grade squamous intraepithelial lesion or worse cytology; HSIL or worse = high grade squamous intraepithelial lesion or worse cytology; HPV 16+ = HPV DNA test positive for HPV 16; HPV 16+ or HPV 18+ = HPV DNA test positive for HPV 16 or HPV 18 or both.