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. 2015 Mar 20;10(3):e0120586. doi: 10.1371/journal.pone.0120586

Fig 6. PECAM-1 inhibition decreased PARP-1 expression and inflammatory response.

Fig 6

After PECAM-1 was inhibited by siRNA, PARP-1 expression and inflammatory response were determined. (A, B, C) The protein expression of PARP-1 and ICAM-1 was analyzed by western blot analysis. (D) TNF-α secretion was assessed by ELISA. (E) IL-1β secretion was assessed by ELISA. (F) THP-1 monocytes adhesion. Values are expressed as mean ± S.D. from three separate experiments. *P<0.05 vs. USS. #P<0.05 vs. LSS. si-PECAM-1: PECAM-1 siRNA; si-NC: negative control of PECAM-1 siRNA.