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In the double islet transplantation model, the first mouse islet graft is used to achieve normoglycemia in diabetic mice. The second minimal human islet graft is allowed a convalescent period before the first mouse graft is removed to induce hyperglycemia (red arrow), and treatment -/+ exendin-4 with a low (20μg/kg/day) or high (200μg/kg/day) dose was initialized.
