Fig 3. Acute administration of exendin-4 improves the oral glucose tolerance test.

Mice transplanted with a minimal human islet graft (250 islets) were treated with or without exendin-4 (20 or 200μg/kg/day) for 15 days. At day 13 day of +/-exendin-4 treatment, an oral glucose tolerance test was performed as indicated in methods. The control group (black line) was compared to non-diabetic controls (pink line), and exendin-4 treated groups (20μg/kg/day (orange line), 200μg/kg/day (green line)). (a) Blood glucose levels during the oral glucose tolerance test with (b) AUC calculated per mice in the different groups. Results are expressed as mean ±SD for each column. **** p< 0.0001 by one-way ANOVA followed by Bonferroni correction vs. saline treated control.